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Cyp4v3tm1(KOMP)Vlcg
Targeted Allele Detail
Nomenclature
Symbol: Cyp4v3tm1(KOMP)Vlcg
Name: cytochrome P450, family 4, subfamily v, polypeptide 3; targeted mutation 1, Velocigene
MGI ID: MGI:3808361
Synonyms: Cyp4v3tm1Vlcg
Gene: Cyp4v3  Location: Chr8:45305801-45333163 bp, - strand  Genetic Position: Chr8, 25.17 cM
Mutation
origin
Mutant Cell Lines:  10578B-B5, 10578B-C11, 10578B-D8, 10578B-F9, 10578B-G3
Germline Transmission:  Earliest citation of germline transmission: J:230232
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
 
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 26040bp between positions 46392290-46418329 of Chromosome 8 (Genome Build37). The cassette replace from part of exon 1 to part of exon 11. Western blot analysis confirmed absence of protein. (J:136110, J:230232)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Cyp4v3 Mutation:  2 strains or lines available
Notes
Cell line 10578B-B5 was successfully used to make chimeric mice. Germline transmission was accomplished. J:230232.
References
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory