About   Help   FAQ
Prl3c1tm1(KOMP)Vlcg
Targeted Allele Detail
Nomenclature
Symbol: Prl3c1tm1(KOMP)Vlcg
Name: prolactin family 3, subfamily c, member 1; targeted mutation 1, Velocigene
MGI ID: MGI:3808306
Synonyms: Prl3c1tm1Vlcg
Gene: Prl3c1  Location: Chr13:27196660-27203749 bp, + strand  Genetic Position: Chr13, 12.32 cM
Mutation
origin
Mutant Cell Lines:  10539A-H5, 10539B-C7, 10539B-D10, 10539B-F4
Germline Transmission:  Earliest citation of germline transmission: J:256588
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
 
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 6904bp between positions 27288578-27295481 of Chromosome 13 (Genome Build37). The entire coding sequence was replaced with an in-frame beta-galactosidase (lacZ) cassette (inserted at the ATG codon in the first exon) followed by a neomycin resistance cassette. (J:136110, J:256588)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 2 lines available
Carrying any Prl3c1 Mutation:  3 strains or lines available
Notes
Cell line 10539B-F4 was successfully used to make chimeric mice. Germline transmission was accomplished. J:256588
References
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/05/2019
MGI 6.14
The Jackson Laboratory