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Targeted Allele Detail
Symbol: Trem2tm1Cln
Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1, Marco Colonna
MGI ID: MGI:3806795
Gene: Trem2  Location: Chr17:48346401-48352276 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:138057
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 and 4 were replaced by a floxed neomycin selection cassette. Chimeric mice were crossed to a CMV-cre transgenic mouse to excise the neo cassette in the germline. Mice were backcrossed to C57BL/6 more than five times. (J:138057)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:  52 strains or lines available
Original:  J:138057 Turnbull IR, et al., Cutting edge: TREM-2 attenuates macrophage activation. J Immunol. 2006 Sep 15;177(6):3520-4
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory