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Targeted Allele Detail
Symbol: Droshatm1.1Litt
Name: drosha, ribonuclease type III; targeted mutation 1.1, Dan R Littman
MGI ID: MGI:3806089
Synonyms: Droshadel, Droshadelta
Gene: Drosha  Location: Chr15:12824815-12935291 bp, + strand  Genetic Position: Chr15, 5.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:138683
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was used to introduce a loxP-flanked neomycin resistance cassette to intron 8, and an additional loxP site to intron 9 of the gene. The mice were crossed with a C57BL/6 background EIIa-Cre line, deleting exon 9 (and the neo cassette). (J:138683)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drosha Mutation:  24 strains or lines available
Original:  J:138683 Chong MM, et al., The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med. 2008 Sep 1;205(9):2005-17
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory