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Targeted Allele Detail
Symbol: Col1a2tm1Mcbr
Name: collagen, type I, alpha 2; targeted mutation 1, Daniel McBride
MGI ID: MGI:3805459
Gene: Col1a2  Location: Chr6:4504814-4541544 bp, + strand  Genetic Position: Chr6, 1.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:178743
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/SvEv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted upstream of exon 35 and a G to T mutation was inserted in exon 35 resulting in a glycine to cysteine mutation at codon 706. (J:178743)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a2 Mutation:  90 strains or lines available
Original:  J:178743 Daley E, et al., Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model. J Bone Miner Res. 2010 Feb;25(2):247-61
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory