Tg(MSLN-TAg)266sLake
Transgene Detail

Summary

• Symbol: Tg(MSLN-TAg)266sLake
• Name: transgene insertion 266s, Richard A Lake
• MGI ID: MGI:3804821
• Synonyms: MexTAg
• Transgene: Tg(MSLN-TAg)266sLake Location: unknown
• Alliance: Tg(MSLN-TAg)266sLake page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 1,850 bp fragment of the human mesothelin promoter drives expression of the SV40 large T antigen. This transgene is expressed in mesothelial cells. Transgenic line 266s carries a single copy of the transgene. In addition, lines 299h, 304i and 270i were also created. (J:116125)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MSLN-TAg)266sLake

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:116125 Robinson C, et al., A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent. Cancer Res. 2006 Nov 15;66(22):10786-94
• All: 3 reference(s)