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Rdh1tm1.1Jln
Targeted Allele Detail
Nomenclature
Symbol: Rdh1tm1.1Jln
Name: retinol dehydrogenase 1 (all trans); targeted mutation 1.1, Joseph Napoli
MGI ID: MGI:3804065
Gene: Rdh1  Location: Chr10:127759721-127768297 bp, + strand  Genetic Position: Chr10, 75.21 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134843
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Transient cre expression in ES cells was used to remove the neo cassette and exon 1. The absence of transcript expression was confirmed by RT-PCR analysis on liver, kidney and testis extracts. (J:134843)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdh1 Mutation:  8 strains or lines available
References
Original:  J:134843 Zhang M, et al., Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007 Sep;21(11):2886-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory