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Mapk1tm1Gela
Targeted Allele Detail
Nomenclature
Symbol: Mapk1tm1Gela
Name: mitogen-activated protein kinase 1; targeted mutation 1, Gary E Landreth
MGI ID: MGI:3803954
Synonyms: ERK2fl, Mapk1flox
Gene: Mapk1  Location: Chr16:16983382-17047453 bp, + strand  Genetic Position: Chr16, 10.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137882
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Transient cre transfection into ES cells was used to remove the neo cassette leaving exon 2 floxed. (J:137882)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk1 Mutation:  19 strains or lines available
References
Original:  J:137882 Samuels IS, et al., Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci. 2008 Jul 2;28(27):6983-95
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory