Tnnt2tm2Mmto
Targeted Allele Detail
|
Symbol: |
Tnnt2tm2Mmto |
Name: |
troponin T2, cardiac; targeted mutation 2, Sachio Morimoto |
MGI ID: |
MGI:3803301 |
Synonyms: |
cTnTdeltaK210, Tnnt2tm1.1Mmto |
Gene: |
Tnnt2 Location: Chr1:135764092-135779998 bp, + strand Genetic Position: Chr1, 59.32 cM
|
Alliance: |
Tnnt2tm2Mmto page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:137784
|
Parent Cell Line: |
CCE/EK.CCE (ES Cell)
|
Strain of Origin: |
129S/SvEv-Gpi1c
|
|
Allele Type: |
|
Targeted (Humanized sequence) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: Exon 13 was replaced with a floxed neo cassette and an exon 13 containing a deletion of three base pairs that results in the deletion of lysine at position 210 (K210). The neo cassette was removed by germ line, cre-mediated recombination. This mutation mimicks one identified in human patients with dilated cardiomyopathy. Similar levels of troponin T protein are detected in cardiac myofibrils isolated from the hearts of mice homozygous for this mutation and of wild-type mice by sodium dodecyl sulftate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis for total protein.
(J:137784, J:173751)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Tnnt2 Mutation: |
52 strains or lines available
|
|
Original: |
J:137784 Du CK, et al., Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. Circ Res. 2007 Jul 20;101(2):185-94 |
All: |
14 reference(s) |
|