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Tnnt2tm2Mmto
Targeted Allele Detail
Nomenclature
Symbol: Tnnt2tm2Mmto
Name: troponin T2, cardiac; targeted mutation 2, Sachio Morimoto
MGI ID: MGI:3803301
Synonyms: cTnTdeltaK210, Tnnt2tm1.1Mmto
Gene: Tnnt2  Location: Chr1:135836354-135852260 bp, + strand  Genetic Position: Chr1, 59.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137784
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 13 was replaced with a floxed neo cassette and an exon 13 containing a deletion of three base pairs that results in the deletion of lysine at position 210 (K210). The neo cassette was removed by germ line, cre-mediated recombination. This mutation mimicks one identified in human patients with dilated cardiomyopathy. Similar levels of troponin T protein are detected in cardiac myofibrils isolated from the hearts of mice homozygous for this mutation and of wild-type mice by sodium dodecyl sulftate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis for total protein. (J:137784, J:173751)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnnt2 Mutation:  39 strains or lines available
References
Original:  J:137784 Du CK, et al., Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. Circ Res. 2007 Jul 20;101(2):185-94
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory