Prom1^tm1Rafi
Targeted Allele Detail

Summary

• Symbol: Prom1^tm1Rafi
• Name: prominin 1; targeted mutation 1, Shahin Rafii
• MGI ID: MGI:3802793
• Synonyms: CD133^lacZ, Prom1^lacZ
• Gene: Prom1 Location: Chr5:44150962-44259374 bp, - strand Genetic Position: Chr5, 23.97 cM
• Alliance: Prom1^tm1Rafi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Using the VelociGene technique, the lacZ gene was knocked into the gene replacing exons 3 through 8. (J:137714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prom1 Mutation: 75 strains or lines available

References

• Original: J:137714 Shmelkov SV, et al., CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest. 2008 Jun;118(6):2111-20
• All: 2 reference(s)