Gata4tm2(Gata4)Wtp
Targeted Allele Detail
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Symbol: |
Gata4tm2(Gata4)Wtp |
Name: |
GATA binding protein 4; targeted mutation 2, William T Pu |
MGI ID: |
MGI:3801683 |
Synonyms: |
Gata4flap |
Gene: |
Gata4 Location: Chr14:63436371-63509141 bp, - strand Genetic Position: Chr14, 33.24 cM
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Alliance: |
Gata4tm2(Gata4)Wtp page
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Germline Transmission: |
Earliest citation of germline transmission:
J:137426
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Inserted expressed sequence, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was replaced with a floxed full-length Gata4 cDNA with a transcription STOP sequence followed by an alkaline phosphatase gene with a 3' frt site. An frt-flanked neo cassette used for selection purposes was removed by germ line, flp-mediated recombination. Cre mediated recombination is necessary to activate alkaline phospatase expression.
(J:137426)
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Original: |
J:137426 Zhou B, et al., Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 3;454(7200):109-13 |
All: |
5 reference(s) |
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