Oxtr^tm1.2Wsy
Targeted Allele Detail

Summary

• Symbol: Oxtr^tm1.2Wsy
• Name: oxytocin receptor; targeted mutation 1.2, W Scott Young III
• MGI ID: MGI:3800792
• Gene: Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
• Alliance: Oxtr^tm1.2Wsy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137445
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 and 3 were removed by germ line, cre-mediated recombination. The absence of protein expression was confirmed by autoradiolabeling with 125-Iodine ornithine vasotocin, an Otx anatagonist. (J:137445)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxtr Mutation: 40 strains or lines available

References

• Original: J:137445 Lee HJ, et al., A conditional knockout mouse line of the oxytocin receptor. Endocrinology. 2008 Jul;149(7):3256-63
• All: 5 reference(s)