About   Help   FAQ
Targeted Allele Detail
Symbol: Mecp2tm1Pplt
Name: methyl CpG binding protein 2; targeted mutation 1, Patrick P L Tam
MGI ID: MGI:3800596
Synonyms: Mecp2tm1neoTam
Gene: Mecp2  Location: ChrX:74026592-74085690 bp, - strand  Genetic Position: ChrX, 37.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:137513
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2 kb segment containing exon 3 through the first 170 bp of exon 4 and encoding the methyl-CpG-binding domain was replaced with a floxed neo cassette. The neo cassette was removed by germ line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis in brain and lung extracts. (J:137513)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  29 strains or lines available
Original:  J:137513 Pelka GJ, et al., Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain. 2006 Apr;129(Pt 4):887-98
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory