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Targeted Allele Detail
Symbol: Mecp2tm1Pplt
Name: methyl CpG binding protein 2; targeted mutation 1, Patrick P L Tam
MGI ID: MGI:3800596
Synonyms: Mecp2tm1neoTam
Gene: Mecp2  Location: ChrX:74026592-74085690 bp, - strand  Genetic Position: ChrX, 37.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:137513
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2 kb segment containing exon 3 through the first 170 bp of exon 4 and encoding the methyl-CpG-binding domain was replaced with a floxed neo cassette. The neo cassette was removed by germ line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis in brain and lung extracts. (J:137513)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  22 strains or lines available
Original:  J:137513 Pelka GJ, et al., Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain. 2006 Apr;129(Pt 4):887-98
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory