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Targeted Allele Detail
Symbol: Bcl2l11tm2Rjd
Name: BCL2-like 11 (apoptosis facilitator); targeted mutation 2, Roger J Davis
MGI ID: MGI:3800457
Synonyms: Bim3SA
Gene: Bcl2l11  Location: Chr2:128126038-128162547 bp, + strand  Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
Germline Transmission:  Earliest citation of germline transmission: J:137061
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA floxed neo cassette was inserted within intron 4, and specific mutations in exon 3 were introduced by homologous recombination. Mutations resuted in three sites of MAPK phosphorylation (Ser-55, Ser-65, and Ser-73) in exon 3 to be substituted with alanines (S55A, S65A, S73A). The neo cassette was then excised with cre recombinase leaving a single loxP site in intron 4. Expression of normal amounts of mutant proteins was confirmed by immunoblot. (J:137061)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2l11 Mutation:  22 strains or lines available
Original:  J:137061 Hubner A, et al., Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell. 2008 May 23;30(4):415-25
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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