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Transgene Detail
Symbol: Tg(Fabp1-GH1)5Bir
Name: transgene insertion 5, Edward H Birkenmeier
MGI ID: MGI:3800317
Synonyms: L-FABP(-4000 to +21)/hGH transgene, long promoter L-FABP-hGH plus pUC, Tg(L-FABP, L-GH)5Bir
Transgene: Tg(Fabp1-GH1)5Bir  Location: unknown  
Strain of Origin:  (C57BL/6J x LT/Sv)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Fabp1-GH1)5Bir expresses 1 gene
Mutation detailsThis transgene comprises a human growth hormone gene whose 5' regulatory elements have been replaced by nucleotides -4000 to +21 from the rat liver fatty-acid binding protein gene; the insertion also contains the pUC13 vector. Mice of this line (from founder G0#1) have ~66 transgene copies per haploid genome, as measured by densitometric analysis of Southern blots. Expression of human growth hormone mRNA, determined by dot-blot analysis, correlates generally with that of endogenous mouse Fabp1 mRNA in liver and intestine, including a proximal-to-distal intestinal expression gradient, highest in the proximal small intestine and declining progressively, though less rapidly for hGH than for Fabp1, through the distal colon. This Fabp1 5' regulatory segment suppresses the expression observed in colon and kidney of mice bearing similar transgenes with a shorter promoter (See Tg(Fabp1-GH1)7Bir, Tg(Fabp1-GH1)10Bir). (J:109939)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:109939 Sweetser DA, et al., Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes. Genes Dev. 1988 Oct;2(10):1318-32
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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