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Mcl1tm1Ywh
Targeted Allele Detail
Nomenclature
Symbol: Mcl1tm1Ywh
Name: myeloid cell leukemia sequence 1; targeted mutation 1, You-Wen He
MGI ID: MGI:3800294
Synonyms: Mcl-1fl
Gene: Mcl1  Location: Chr3:95658788-95663176 bp, + strand  Genetic Position: Chr3, 40.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137502
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA lox P site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:137502)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcl1 Mutation:  30 strains or lines available
References
Original:  J:137502 Dzhagalov I, et al., The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood. 2007 Feb 15;109(4):1620-6
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory