Mdc1^{Gt(OST441263)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Mdc1^{Gt(OST441263)Lex}
• Name: mediator of DNA damage checkpoint 1; gene trap OST441263, Lexicon Genetics
• MGI ID: MGI:3799747
• Synonyms: MDC1^-
• Gene: Mdc1 Location: Chr17:36152407-36170562 bp, + strand Genetic Position: Chr17, 18.7 cM
• Alliance: Mdc1^{Gt(OST441263)Lex} page

Mutation origin

• Mutant Cell Line: OST441263
• Germline Transmission: Earliest citation of germline transmission: J:137341
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector VICTR48 was inserted between exon 1 and exon 2. Loss of Mdc1 expression was confirmed by immunoblotting in testes and MEFs isolated from homozygous mutants. (J:137341)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST441263	CG660889 ; (MGI Seq Detail)	3' RACE	Chr17:36155328-36157211 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  29 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mdc1^{Gt(OST441263)Lex}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mdc1 Mutation: 73 strains or lines available

References

• Original: J:137341 Lou Z, et al., MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan 20;21(2):187-200
• All: 11 reference(s)