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Add1tm1Llp
Targeted Allele Detail
Nomenclature
Symbol: Add1tm1Llp
Name: adducin 1 (alpha); targeted mutation 1, Luanne Peters
MGI ID: MGI:3799499
Gene: Add1  Location: Chr5:34573664-34632308 bp, + strand  Genetic Position: Chr5, 17.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138919
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Add1 Mutation:  349 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hydrocephalus in homozygous mice (J:138919)

References
Original:  J:138919 Robledo RF, et al., Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Blood. 2008 Nov 15;112(10):4298-307
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory