Lpin1^tm1Rchr
Targeted Allele Detail

Summary

• Symbol: Lpin1^tm1Rchr
• Name: lipin 1; targeted mutation 1, Roman Chrast
• MGI ID: MGI:3799353
• Synonyms: Lp^fE2-3
• Gene: Lpin1 Location: Chr12:16585670-16696967 bp, - strand Genetic Position: Chr12, 7.9 cM
• Alliance: Lpin1^tm1Rchr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:137213)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpin1 Mutation: 56 strains or lines available

References

• Original: J:137213 Nadra K, et al., Phosphatidic acid mediates demyelination in Lpin1 mutant mice. Genes Dev. 2008 Jun 15;22(12):1647-61
• All: 14 reference(s)