Lrp2^m267Asp
Chemically induced Allele Detail

Summary

• Symbol: Lrp2^m267Asp
• Name: low density lipoprotein receptor-related protein 2; mutation 267, Andrew S Peterson
• MGI ID: MGI:3799273
• Synonyms: megalin^line267
• Gene: Lrp2 Location: Chr2:69254679-69416373 bp, - strand Genetic Position: Chr2, 40.74 cM
• Alliance: Lrp2^m267Asp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a nucleotide transversion that resulted in an amino acid substitution of a stop codon for tyrosine at position 2721 in the complement repeats domain. This mutation results in the exclusion of the transmembrane domain. (J:136795)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp2 Mutation: 260 strains or lines available

References

• Original: J:136795 Zarbalis K, et al., A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug;2(8):E219
• All: 5 reference(s)