Tg(APOE-NPC1L1)20Lqyu
Transgene Detail
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Symbol: |
Tg(APOE-NPC1L1)20Lqyu |
Name: |
transgene insertion 20, Liqing Yu |
MGI ID: |
MGI:3799059 |
Synonyms: |
L1-Tg20, NPC1L1LiverTg, NPCL1-Tg-Mod |
Transgene: |
Tg(APOE-NPC1L1)20Lqyu Location: unknown
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Alliance: |
Tg(APOE-NPC1L1)20Lqyu page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APOE-NPC1L1)20Lqyu expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
NPC1L1 (29881) |
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Mutation details: A transgenic construct containing the human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) gene under the control of the human apolipoprotein E (APOE) promoter and hepatic control region was injected into fertilized B6D2F1/Hsd mouse eggs. Two lines were established, L1-Tg20 and L1-Tg112. Transgene expression is detected in liver by Western blot analysis and is localized to the canalicular membrane.
(J:124193)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:124193 Temel RE, et al., Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007 Jul;117(7):1968-78 |
All: |
6 reference(s) |
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