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Transgene Detail
Symbol: Tg(APOE-NPC1L1)20Lqyu
Name: transgene insertion 20, Liqing Yu
MGI ID: MGI:3799059
Synonyms: L1-Tg20, NPC1L1LiverTg, NPCL1-Tg-Mod
Transgene: Tg(APOE-NPC1L1)20Lqyu  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(APOE-NPC1L1)20Lqyu expresses 1 gene
Mutation detailsA transgenic construct containing the human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) gene under the control of the human apolipoprotein E (APOE) promoter and hepatic control region was injected into fertilized B6D2F1/Hsd mouse eggs. Two lines were established, L1-Tg20 and L1-Tg112. Transgene expression is detected in liver by Western blot analysis and is localized to the canalicular membrane. (J:124193)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:124193 Temel RE, et al., Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007 Jul;117(7):1968-78
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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