Dgcr2^tm1Aam
Targeted Allele Detail

Summary

• Symbol: Dgcr2^tm1Aam
• Name: DiGeorge syndrome critical region gene 2; targeted mutation 1, Alea A Mills
• MGI ID: MGI:3798958
• Gene: Dgcr2 Location: Chr16:17658219-17709592 bp, - strand Genetic Position: Chr16, 11.05 cM, cytoband A-B1
• Alliance: Dgcr2^tm1Aam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136969
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 1 and 2 of the Hprt gene along with a 3' loxP site and neo cassette were inserted into the coding region to create the starting point of a 1.3 Mb genomic deletion as a model for a 1.5 Mb hemizygous deletion in certain 22q11-deletion syndrome patients. (J:136969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dgcr2 Mutation: 24 strains or lines available

References

• Original: J:136969 Stark KL, et al., Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet. 2008 Jun;40(6):751-60
• All: 1 reference(s)