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Fbxw7tm1Iaai
Targeted Allele Detail
Nomenclature
Symbol: Fbxw7tm1Iaai
Name: F-box and WD-40 domain protein 7; targeted mutation 1, Iannis Aifantis
MGI ID: MGI:3798866
Synonyms: Fbw7flox
Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137138
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv x C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted downstream of exon 4 and an frt- and loxP-flanked neo cassette was inserted downstream of exon 6. Germ line, frt-mediated recombination was used to remove the neo cassette leaving exons 5 and 6 floxed. (J:137138)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  64 strains or lines available
References
Original:  J:137138 Thompson BJ, et al., Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med. 2008 Jun 9;205(6):1395-408
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory