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Pkp3tm1.1Fvr
Targeted Allele Detail
Nomenclature
Symbol: Pkp3tm1.1Fvr
Name: plakophilin 3; targeted mutation 1.1, Frans van Roy
MGI ID: MGI:3798862
Gene: Pkp3  Location: Chr7:141078229-141090511 bp, + strand  Genetic Position: Chr7, 86.34 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136451
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsGerm line, cre-mediated recombination was used to remove exons 2-4. The absence of protein product was confirmed by western blot analysis on skin extracts. (J:136451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkp3 Mutation:  3 strains or lines available
References
Original:  J:136451 Sklyarova T, et al., Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol. 2008 Jun;128(6):1375-85
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory