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Kdm5atm1.1Kael
Targeted Allele Detail
Nomenclature
Symbol: Kdm5atm1.1Kael
Name: lysine (K)-specific demethylase 5A; targeted mutation 1.1, William G Kaelin
MGI ID: MGI:3798768
Gene: Kdm5a  Location: Chr6:120341085-120421535 bp, + strand  Genetic Position: Chr6, 56.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137185
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was generated by flanking exons 5 and 6 with a 5' loxP site and a 3' Frt-PGK-neomycin-Frt-LoxP expression cassette. Germline transmitting mice were bred sequentially with CAGG-Flpe mice to remove the neo cassette, and then to EIIa-Cre transgenic mice in FVB background to generate the null allele. (J:137185)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdm5a Mutation:  47 strains or lines available
References
Original:  J:137185 Klose RJ, et al., The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 2007 Mar 9;128(5):889-900
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory