Egr2^tm4Pch
Targeted Allele Detail

Summary

• Symbol: Egr2^tm4Pch
• Name: early growth response 2; targeted mutation 4, Patrick Charney
• MGI ID: MGI:3798483
• Synonyms: Krox20^I268F
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm4Pch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137156
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: A nucleotide transversion converted codon TTC to ATC resulting in the amino acid substitution of phenylalanine for isoleucine at position 268 (I268F). A floxed neo cassette used for selection purposes was removed by germ line, cre-mediated recombination. (J:137156)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 31 strains or lines available

References

• Original: J:137156 Desmazieres A, et al., Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution. J Neurosci. 2008 Jun 4;28(23):5891-900
• All: 1 reference(s)