Gria1^tm2Rsp
Targeted Allele Detail

Summary

• Symbol: Gria1^tm2Rsp
• Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 2, Rolf Sprengel
• MGI ID: MGI:3798452
• Synonyms: GluR1^flox, GluR-A^2lox, GRIA1^fl
• Gene: Gria1 Location: Chr11:56902342-57221070 bp, + strand Genetic Position: Chr11, 34.51 cM
• Alliance: Gria1^tm2Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55695
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted 700 bp into exon 11 along with an additional loxP site inserted upstream of exon 10. This allele was used to generate Gria1^tm1Rsp by transfecting targeted ES cells with a cre-expressing vector (pMC-cre). (J:55695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria1 Mutation: 62 strains or lines available

References

• Original: J:55695 Zamanillo D, et al., Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning [see comments]. Science. 1999 Jun 11;284(5421):1805-11
• All: 39 reference(s)