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Targeted Allele Detail
Symbol: Gria1tm2Rsp
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 2, Rolf Sprengel
MGI ID: MGI:3798452
Synonyms: GluR1flox, GluR-A2lox, GRIA1fl
Gene: Gria1  Location: Chr11:57011571-57330244 bp, + strand  Genetic Position: Chr11, 34.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:55695
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted 700 bp into exon 11 along with an additional loxP site inserted upstream of exon 10. This allele was used to generate Gria1tm1Rsp by transfecting targeted ES cells with a cre-expressing vector (pMC-cre). (J:55695)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:  11 strains or lines available
Original:  J:55695 Zamanillo D, et al., Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning [see comments]. Science. 1999 Jun 11;284(5421):1805-11
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory