Ins2^tm1Jrc
Targeted Allele Detail

Summary

• Symbol: Ins2^tm1Jrc
• Name: insulin II; targeted mutation 1, J Richard Chaillet
• MGI ID: MGI:3798435
• Synonyms: InsII^EGFP
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^tm1Jrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137004
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A floxed neo cassette and EGFP coding sequence were inserted into exon 3. Transient cre expression in ES cells was used to remove the cre cassette. EGFP is expressed in insulin-producing beta cells of the islet of Langerhans. (J:137004)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 90 strains or lines available

References

• Original: J:137004 Ben-Yehudah A, et al., Specific dynamic and noninvasive labeling of pancreatic beta cells in reporter mice. Genesis. 2005 Dec;43(4):166-74
• All: 1 reference(s)