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Targeted Allele Detail
Symbol: Sosttm1(KOMP)Vlcg
Name: sclerostin; targeted mutation 1, Velocigene
MGI ID: MGI:3797839
Synonyms: SostLacZ, SostLacZ-neo, Sosttm1Vlcg
Gene: Sost  Location: Chr11:101962458-101967015 bp, - strand  Genetic Position: Chr11, 65.48 cM, cytoband D
Higher bone mass in Rr20tm1.1Vlcg/Rr20tm1.1Vlcg and Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg mice

Show the 1 phenotype image(s) involving this allele.

Mutant Cell Lines:  10069A-G10, 10069B-C7, 10069B-C10, 10069B-E8 (Velocigene)
Germline Transmission:  Earliest citation of germline transmission: J:167585
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 3174bp between positions 101825111-101828284 of Chromosome 11 (Genome Build37). (J:136110, J:167585)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Sost Mutation:  6 strains or lines available
Cell line 10069B-C10 was successfully used to make chimeric mice. Germline transmission was accomplished. J:188586
Cell line 10069A-G10 was successfully used to make chimeric mice. Germline transmission was accomplished. J:167585

Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory