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Targeted Allele Detail
Symbol: Timp3tm1Hest
Name: tissue inhibitor of metalloproteinase 3; targeted mutation 1, Heidi Stohr
MGI ID: MGI:3797605
Gene: Timp3  Location: Chr10:86300372-86349506 bp, + strand  Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
Germline Transmission:  Earliest citation of germline transmission: J:136890
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neo cassette was inserted into exon 3 leading to a frame shift and the introduction of a premature stop codon. The absence of protein product was confirmed by western blot analysis on primary fibroblast extracts. (J:136890)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Timp3 Mutation:  4 strains or lines available
Original:  J:136890 Janssen A, et al., Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2812-22
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory