Mecp2^tm1Csb
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm1Csb
• Name: methyl CpG binding protein 2; targeted mutation 1, Cecile Spielewoy Blaustein
• MGI ID: MGI:3797096
• Synonyms: MeCP2-EGFP
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm1Csb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136605
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing an EGFP, a STOP codon and a floxed neo was inserted at the STOP translation codon to create a fusion gene. Germ line, cre-mediated recombnation was used to remove the neo cassette. (J:136605)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 38 strains or lines available

References

• Original: J:136605 Schmid RS, et al., A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome. Neuroreport. 2008 Mar 5;19(4):393-8
• All: 1 reference(s)