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Enamtm1.1Jcch
Targeted Allele Detail
Nomenclature
Symbol: Enamtm1.1Jcch
Name: enamelin; targeted mutation 1.1, Jan C C Hu
MGI ID: MGI:3796583
Synonyms: EnamlacZ
Gene: Enam  Location: Chr5:88487975-88506049 bp, + strand  Genetic Position: Chr5, 43.66 cM, cytoband E2
Tooth abnormalities in Enamtm1.1Jcch/Enam+ and Enamtm1.1Jcch/Enamtm1.1Jcch mice at 7 weeks of age

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136524
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 3 through exon 7 was replaced with a lacZ and floxed neo cassette. The neo cassette was subsequently removed by crossing targeted mice with transgenic mice expressing cre recombinase in the germline. The absence of protein product was confirmed by western blot analysis on enamel extracts. This is a reporter allele and a null allele. (J:136524)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Enam Mutation:  6 strains or lines available
References
Original:  J:136524 Hu JC, et al., Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice. J Biol Chem. 2008 Apr 18;283(16):10858-71
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory