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Sfrp1tm1Jrbn
Targeted Allele Detail
Nomenclature
Symbol: Sfrp1tm1Jrbn
Name: secreted frizzled-related protein 1; targeted mutation 1, Jeffrey Rubin
MGI ID: MGI:3796251
Synonyms: Sfrp1lacZ, Sfrp1tm1Pcma
Gene: Sfrp1  Location: Chr8:23411502-23449632 bp, + strand  Genetic Position: Chr8, 11.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136160
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neo cassette was inserted downstream of the initiation methionine codon in exon 1 replacing the endogenous sequence. The absence of protein product was confirmed by western blot analysis on prostate and seminal vesicle extracts. (J:136160)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 43 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sfrp1 Mutation:  5 strains or lines available
References
Original:  J:136160 Joesting MS, et al., Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol. 2008 May 1;317(1):161-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory