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Targeted Allele Detail
Symbol: Cebpatm8.1Nerl
Name: CCAAT/enhancer binding protein (C/EBP), alpha; targeted mutation 8.1, Claus Nerlov
MGI ID: MGI:3796230
Synonyms: CbpaL, CebpaLp30
Gene: Cebpa  Location: Chr7:35119293-35121928 bp, + strand  Genetic Position: Chr7, 21.02 cM
Germline Transmission:  Earliest citation of germline transmission: J:136134
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsGerm line, cre-mediated recombination was used to remove the neo cassette and results in a missense mutation that produces a STOP codon upstream of the coding region of p42. The absence of p42 and presence of p30 protein products was confirmed by western blot analysis of liver extracts. (J:136134)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpa Mutation:  7 strains or lines available
Original:  J:136134 Kirstetter P, et al., Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell. 2008 Apr;13(4):299-310
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.07
The Jackson Laboratory