Aicda^tm2Mnz
Targeted Allele Detail

Summary

• Symbol: Aicda^tm2Mnz
• Name: activation-induced cytidine deaminase; targeted mutation 2, Michel C Nussenzweig
• MGI ID: MGI:3796170
• Synonyms: Aicda¹⁵⁵
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm2Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136224
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Mirn155 seed sequence was removed from the 3'UTR and a self-excising neo cassette downstream of exon 4. The final allele does not contain the neo cassette. (J:136224)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 55 strains or lines available

References

• Original: J:136224 Dorsett Y, et al., MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity. 2008 May;28(5):630-8
• All: 2 reference(s)