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Targeted Allele Detail
Symbol: Dicer1tm1.1Mmk
Name: dicer 1, ribonuclease type III; targeted mutation 1.1, Matthias Merkenschlager
MGI ID: MGI:3795355
Synonyms: dcrdelta
Gene: Dicer1  Location: Chr12:104687742-104751952 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Germline Transmission:  Earliest citation of germline transmission: J:135783
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 20 and 21, which contain the RNaseII domain, were removed by germ line, cre-mediated recombination. No functional protein product is expected to be produced. (J:135783)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  61 strains or lines available
Original:  J:135783 Koralov SB, et al., Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008 Mar 7;132(5):860-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory