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Tg(GPD1)A2Bir
Transgene Detail
Nomenclature
Symbol: Tg(GPD1)A2Bir
Name: transgene insertion A2, Edward H Birkenmeier
MGI ID: MGI:3795211
Synonyms: GPDH-A2
Transgene: Tg(GPD1)A2Bir  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x LT/Sv)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(GPD1)A2Bir expresses 1 gene
 
Mutation detailsThe transgene comprises 12.3 kb of human genomic DNA containing the GPD1 gene, consisting of 3.5 kb of 5' flanking sequence, the 7.6 kb protein-coding region and 1.2 kb of 3' flanking DNA. The 5' flanking sequence includes the proximal and distal promoter regions. Founder line A2 has approximately 14 copies of the transgene. Mice exhibit a much higher level of transgene expression in the cerebral cortex and kidney than is normal for the endogenous gene. (J:135002)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:135002 Birkenmeier EH, et al., Tissue- and cell-specific expression of human sn-glycerol-3-phosphate dehydrogenase in transgenic mice. Nucleic Acids Res. 1992 Jun 11;20(11):2819-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory