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Transgene Detail
Symbol: Tg(GPD1)A1Bir
Name: transgene insertion A1, Edward H Birkenmeier
MGI ID: MGI:3795209
Synonyms: GPDH-A1
Transgene: Tg(GPD1)A1Bir  Location: unknown  
Strain of Origin:  (C57BL/6J x LT/Sv)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(GPD1)A1Bir expresses 1 gene
Mutation detailsThe transgene comprises 12.3 kb of human genomic DNA containing the GPD1 gene, consisting of 3.5 kb of 5' flanking sequence, the 7.6 kb protein-coding region and 1.2 kb of 3' flanking DNA. The 5' flanking sequence includes the proximal and distal promoter regions. Founder line A1 has approximately 6 copies of the transgene. Mice exhibit a much higher level of transgene expression in the cerebral cortex than is normal for the endogenous gene. (J:135002)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:135002 Birkenmeier EH, et al., Tissue- and cell-specific expression of human sn-glycerol-3-phosphate dehydrogenase in transgenic mice. Nucleic Acids Res. 1992 Jun 11;20(11):2819-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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