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Targeted Allele Detail
Symbol: Pdpk1tm1Dral
Name: 3-phosphoinositide dependent protein kinase 1; targeted mutation 1, Dario R Alessi
MGI ID: MGI:3795190
Synonyms: PDK1K465E
Gene: Pdpk1  Location: Chr17:24073680-24150924 bp, - strand  Genetic Position: Chr17, 12.23 cM, cytoband A3.3
Germline Transmission:  Earliest citation of germline transmission: J:136089
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 12 wass replaced with a floxed neo cassette and an exon 12 containing a nucleotide substitution that results in the amino acid substitution of glutamic acid for lysine at position 465 (K465E). The neo cassette was removed by germ line, cre-mediated recombination. (J:136089)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpk1 Mutation:  124 strains or lines available
Original:  J:136089 Bayascas JR, et al., Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol. 2008 May;28(10):3258-72
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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