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Ace2tm1Hira
Targeted Allele Detail
Nomenclature
Symbol: Ace2tm1Hira
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; targeted mutation 1, Hiromi Rakugi
MGI ID: MGI:3794966
Gene: Ace2  Location: ChrX:164139342-164188418 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135766
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neo cassette. The absence of protein product was confirmed by westen blot analysis. (J:135766)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  13 strains or lines available
References
Original:  J:135766 Yamamoto K, et al., Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension. 2006 Apr;47(4):718-26
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory