Tcrg^tm1Hish
Targeted Allele Detail

Summary

• Symbol: Tcrg^tm1Hish
• Name: T cell receptor gamma chain; targeted mutation 1, Hiromichi Ishikawa
• MGI ID: MGI:3794896
• Synonyms: Vgamma6deltaL-Cgamma4deltaNL
• Gene: Tcrg Location: Chr13:19362212-19540646 bp, + strand Genetic Position: Chr13, cytoband A2-A3

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135597
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: ES cell containing the Tcrg^tm1Iku allele, which has the Vgamma6 gene segment replaced with a loxP site, was targeted a second time. Exon 1 of constant region 4 was replaced with a neo cassette containing a downstream loxP site. (J:135597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrg Mutation: 1 strain or line available

References

• Original: J:135597 Nanno M, et al., Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice. Gastroenterology. 2008 Feb;134(2):481-90
• All: 1 reference(s)