About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Wt1tm1Mlh
Name: Wilms tumor 1 homolog; targeted mutation 1, Martin L Hooper
MGI ID: MGI:3794650
Synonyms: Wt1tmT396
Gene: Wt1  Location: Chr2:105126529-105173616 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:135449
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 9 was replaced with one that contains an inserted Leu2/neo cassette that causes an amino acid substitution of arginine for serine at position 395 and premature termination within the zinc finger 3 domain by inclusion of a translation stop codon at position 396. (J:135449)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:  8 strains or lines available
Original:  J:135449 Patek CE, et al., Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1 (tmT396)). Transgenic Res. 2008 Jun;17(3):459-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory