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Mtbptm1Glo
Targeted Allele Detail
Nomenclature
Symbol: Mtbptm1Glo
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein; targeted mutation 1, Guillermina Lozano
MGI ID: MGI:3794647
Gene: Mtbp  Location: Chr15:55557408-55626423 bp, + strand  Genetic Position: Chr15, 22.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135509
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ gene followed by a neo cassette was inserted immediately downstream of the initiation methionine in exon 1. The absence of protein product from this allele was confirmed by western blot analysis on heterozygous thymocytes. This is a null allele and a reporter allele. (J:135509)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtbp Mutation:  43 strains or lines available
References
Original:  J:135509 Iwakuma T, et al., Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene. 2008 Mar 20;27(13):1813-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory