Tg(APOE-SLCO1B3)2Nki
Transgene Detail

Summary

• Symbol: Tg(APOE-SLCO1B3)2Nki
• Name: transgene insertion 2, The Netherlands Cancer Institute
• MGI ID: MGI:3794299
• Transgene: Tg(APOE-SLCO1B3)2Nki Location: unknown
• Alliance: Tg(APOE-SLCO1B3)2Nki page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Expression of human SLCO1B3 (OATP1B3) cDNA and an HA-tag sequence is driven by the human APOE/hepatic control region. Primary expression is in hepatocytes. (J:262144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:262144 van de Steeg E, et al., Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice. Clin Cancer Res. 2013 Feb 15;19(4):821-32
• All: 1 reference(s)