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Tg(Pbsn-TAg)15Tvd
Transgene Detail
Nomenclature
Symbol: Tg(Pbsn-TAg)15Tvd
Name: transgene insertion 15, Terry Van Dyke
MGI ID: MGI:3794201
Synonyms: PB-TagAPT121, TgAPT121
Transgene: Tg(Pbsn-TAg)15Tvd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe 458pb ARR2PB promoter which is regulated by androgens and is activated during puberty was used to drive expression of the truncated SV40 large T antigen but not the small t antigen. The translation product contains the first 121 amino acids of SV40 T followed by 11 missense amino acids. (J:103408)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:103408 Hill R, et al., Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model. Cancer Res. 2005 Nov 15;65(22):10243-54
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory