Abcc12^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Abcc12^tm1Bor
• Name: ATP-binding cassette, sub-family C member 12; targeted mutation 1, Piet Borst
• MGI ID: MGI:3794121
• Gene: Abcc12 Location: Chr8:87231197-87307317 bp, - strand Genetic Position: Chr8, 42.06 cM, cytoband D3
• Alliance: Abcc12^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125562
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: An oligonucleotide targeting strategy was used to introduce a frame-shift and consequently a premature stop codon in the open reading frame by the insertion of 4 bp into exon 2 (the first coding exon) between codons 13 and 14. This allele produces a truncated protein that lacks the amino terminal segment (31 amino acids) due to the presence of an alternative in-frame initiation codon 19 codons downstream. (J:125562)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc12 Mutation: 51 strains or lines available

References

• Original: J:125562 Ono N, et al., Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm. Biochem J. 2007 Aug 15;406(1):31-40
• All: 1 reference(s)