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Abcc5tm1Bor
Targeted Allele Detail
Nomenclature
Symbol: Abcc5tm1Bor
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 5; targeted mutation 1, Piet Borst
MGI ID: MGI:3794119
Gene: Abcc5  Location: Chr16:20331303-20426394 bp, - strand  Genetic Position: Chr16, 12.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135561
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.5 kb segment of genomic DNA containing exon 17 that encodes amino acids 678 to 745 of the first ATP-binding domain was replaced with a hygro cassette. The absence of protein product was confirmed by western blot analysis on erythrocye vesicle extracts. (J:135561)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc5 Mutation:  111 strains or lines available
References
Original:  J:135561 de Wolf CJ, et al., cGMP transport by vesicles from human and mouse erythrocytes. FEBS J. 2007 Jan;274(2):439-50
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory