Tg(MMTV-Akt1*T308D*S473D)7Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-Akt1*T308D*S473D)7Mul
• Name: transgene insertion 7, William J Muller
• MGI ID: MGI:3794053
• Synonyms: Akt7, MMTV-Akt1-DD, MMTV/AktDD-7
• Transgene: Tg(MMTV-Akt1*T308D*S473D)7Mul Location: unknown
• Alliance: Tg(MMTV-Akt1*T308D*S473D)7Mul page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains a constitutively active mouse Akt1, in which critical residues (T308D/S473D) for activation of Akt1 are replaced by negatively charged amino acids, under the control of the mouse mammary tumor virus LTR. Mammary glands express significant levels of the transgene. (J:68521)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:68521 Hutchinson J, et al., Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol. 2001 Mar;21(6):2203-12
• All: 3 reference(s)