Tg(MMTV-Erbb2*)YD5Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-Erbb2*)YD5Mul
• Name: transgene insertion YD5, William J Muller
• MGI ID: MGI:3794036
• Synonyms: MMTV-NeuYD
• Transgene: Tg(MMTV-Erbb2*)YD5Mul Location: unknown
• Alliance: Tg(MMTV-Erbb2*)YD5Mul page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Erbb2*)YD5Mul expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: A rat Erbb2 cDNA containing an activating mutation and point mutations in the catalytic domain is expressed under the control of the MMTV LTR with SV40 polyadenylation and splicing signals. The activating mutation, derived from a clone isolated from mouse mammary tumor tissue, consists of a 12 codon in-frame deletion (neu8142 or NDL1) in the region encoding the extracellular region directly adjacent to the transmembrane domain. In addition, sequences encoding the tyrosine kinase domain were altered to mutate residues 1028 (site A), 1144 (site B), 1201 (site C), and 1253 (site E) from tyrosine to phenylalanine. An additional tyrosine residue at 1226/1227 (site D) was not mutated. Expression of the transgene in mammary tissue was confirmed by RT-PCR. (J:67363)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2*)YD5Mul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:67363 Dankort D, et al., Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol Cell Biol. 2001 Mar;21(5):1540-51
• All: 12 reference(s)